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pentobarbital will lessen the level or impact of theophylline by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Watch.pentobarbital will lessen the level or impact of roflumilast by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Coadministration not recommended; potent cytochrome P450 enzyme inducers min